Early Alzheimer’s trials: New developments

Some New Developments in Small Area Estimation

Small area estimation has received a lot of attention in recent years due to growing demand for reliable small area statistics. Traditional area-specific estimators may not provide adequate precision because sample sizes in small areas are seldom large enough. This makes it necessary to employ indirect estimators based on linking models. Basic area level and unit level models have been extensiv...

Size of beef cows: early ideas, new developments.

Pharmacodynamics of levofloxacin: a new paradigm for early clinical trials.

CONTEXT One purpose of early clinical trials is to establish the appropriate dose of an antibiotic for phase 3 trials. Development of a relationship between the ratio of drug exposure to organism minimum inhibitory concentration (MIC) and therapeutic response early in the development process would allow an optimal choice of dose to maximize response. OBJECTIVE To prospectively quantitate the ...

Early Developments in Nonlinear Control

This article presents a review of some of the early develop­ ments in nonlinear control engineering. It begins by briefly examining the status prior to World War II and then concentrates on the developments in approximately the following two dec­ ades. A significant amount of the work will be seen to have as its foundation the need to obtain methods to solve wartime problems related to servomec...

Early Developments in Joint Action.

Joint action, critical to human social interaction and communication, has garnered increasing scholarly attention in many areas of inquiry, yet its development remains little explored. This paper reviews research on the growth of joint action over the first 2 years of life to show how children become progressively more able to engage deliberately, autonomously, and flexibly in joint action with...